| 摘要 |
Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn2+, Mg2+, Si2+, Na+, K+, Sr2+, Cu2+, Fe3+/Fe2+, Ag+, Ti4+, CO32−, F−, MgO, ZnO, NaF, KF, FeO/Fe2O3, SrO, CuO, SiO2, TiO2, Ag2O and CaCO3, present in an amount between 0 and about 10 w %, from about 0.5 to about 5 w %, or from about 1 to about 3 w %, and methods of using same. |
| 主权项 |
1. A method of providing a biocompatible ceramic material for bioengineering, restoring, or regenerating a tissue, the method comprising:
determining an ex vivo degradation rate of a plurality of biocompatible ceramic materials each including a three-dimensional scaffold ceramic material composed of calcium phosphate ceramic sintered with a dopant uniformly distributed therein; wherein determining the ex vivo degradation rate includes:
placing the plurality of biocompatible ceramic materials under body fluid or simulated body fluid conditions; andmeasuring a loss of mechanical strength of the individual biocompatible ceramic materials after a period of time; and selecting and providing one of the biocompatible ceramic materials for implantation in an environment associated with a tissue having a growth rate such that the ex vivo degradation rate of the one of the selected biocompatible ceramic materials correlates with the growth rate of the tissue, wherein the dopant is present in an amount sufficient to maintain the compressive strength of the biocompatible ceramic material at about 30% of original or higher, 40% of original or higher, 50% of original or higher, 60% of original or higher, 70% of original or higher, 80% of original or higher, or 90% of original or higher, in each case, for a period of at least 6, at least 7, least 8, at least 9, at least 10, at least 11 or at least 12 months under body, body fluid or simulated body fluid conditions. |
