The present invention relates to processes for making (see formula I and II), which are intermediates that may be used in the preparation of modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator. G4 and G5 are as defined in the specification. The invention also relates to (see formula III).
申请公布号
CA2571949(C)
申请公布日期
2015.05.12
申请号
CA20052571949
申请日期
2005.06.24
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
HADIDA-RUAH, SARA;HAZLEWOOD, ANNA R.;GROOTENHUIS, PETER D.J.;VAN GOOR, FREDRICK F.;SINGH, ASHVANI K.;ZHOU, JINGLAN;MCCARTNEY, JASON