| 主权项 |
1. A compound of formula (I): wherein X represents N or CH; Rl is selected from the group consisting of tert-butyl, CF3 and cyclopropyl; R2 represents substructure (T1): wherein E represents O or S; o represents 0 or 1; R10a and R10b are each independently selected from the group consisting of H, methyl and ethyl; m represents 0 or 1; and G is selected from the group consisting of a cycloaliphatic group, a heterocycloaliphatic group, and an aryl group, wherein the cycloaliphatic group or the heterocycloaliphatic group is selected from the group consisting of cyclohexyl and piperidinyl, in each case unsubstituted or mono- or polysubstituted with one or more substituents each independently selected from the group consisting of F, Cl, Br, I, OH, C1-4 alkyl, O—C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, and phenyl, wherein phenyl can be unsubstituted or mono- or polysubstituted with one or more substituents each independently selected from the group consisting of F, Cl, Br, I, CN, OH, O—C1-4 alkyl, OCF3, C1-4 alkyl, CF3, and SCF3; and wherein the an aryl group is phenyl, unsubstituted or mono- or polysubstituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, CN, OH, O—C1-4 alkyl, OCF3, C1-4 alkyl, CF3, SCF3, NH2, NH(C1-4 alkyl) and N(C1-4 alkyl)2; n represents 1; R3 is H; R4a represents H or methyl; Y represents O; Z represents N or C—R4b; R4b represents H; T1 represents N or C—R5; U1 represents N or C—R6; V represents N or C—R7; U2 represents C—R8; T2 represents C—R9; with the proviso that 1 or 2 of variables T1, U1, and V represent a nitrogen atom; and R5 and R6 together, or R6 and R7 together, or R7 and R8 together, or R8 and R9 together, in pairs in each case independently of one another, together with the carbon atoms connecting them form a C5—C6-cycloaliphatic residue or a 5 to 6 membered heterocycloaliphatic residue, in each case unsubstituted or mono- or polysubstituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, C1-4 alkyl, C1-4 alkyl-OH, C(═O)—C1-4 alkyl, O—C1-4 alkyl, O—C1-4 alkylene-OH, O—C1-4 alkylene-O—C1-4 alkyl, OH, SO2—C1-4 alkyl, NH2, NH—C1-4 alkyl, N(C1-4 alkyl)2, NH—SO2—C1-4 alkyl and NH—C(═O)—C1-4 alkyl, wherein the heterocycloaliphatic residue comprises 1 or 2 atoms selected from the group consisting of N and O, or in pairs in each case independently of one another, together with the carbon atoms connecting them form an aryl, or a 5-6 membered heteroaryl, in each case unsubstituted or mono- or polysubstituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, C1-4 alkyl, C1-4 alkyl-OH, C(═O)—C1-4 alkyl, O—C1-4 alkyl, O—C1-4 alkylene-OH, O—C1-4 alkylene-O—C1-4 alkyl, OH, SO2—C1-4 alkyl, NH2, NH—C1-4 alkyl, N(C1-4 alkyl)2, NH—SO2—C1-4 alkyl and NH—C(═O)—C1-4 alkyl, wherein the heteroaryl comprises 1 or 2 atoms selected from the group consisting of N, O, and S, and the respective remaining substituents of R5, R6, R7, R8, and R9 each independently represent H; F; Cl; Br; I; CF3; OH; OCF3; O—C1-4 alkyl, O—C1-4 alkylene-OH, C1-4 alkyl, C1-4 alkyl-OH, NH2; NH—C1-4 alkyl, N(C1-4 alkyl)2, NH—SO2—C1-4 alkyl, NH—C(═O)—C1-4 alkyl, SCF3; or SO2—C1-4 alkyl; optionally in the form of a single stereoisomer or a mixture of stereoisomers, in the form of the free compound and/or a physiologically acceptable salt thereof. |
