Chitosan-derivative compounds and methods of controlling microbial populations

摘要

The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.

主权项

1. An oral care method for controlling microbial activity in an individual comprising administering functionalized chitosan-arginine compounds that are soluble at physiologic pH, in a therapeutically effective amount and in a therapeutically effective excipient, wherein the compounds are between 2% and 50% functionalized; are substantially free of compounds having a molecular weight of less than 5000 Da, and wherein the compounds are substantially free of polyarginine polymers.