P97 protein and uses thereof as vaccine adjuvant

摘要

Immunogenic compositions comprising a p97 adhesin adjuvant polypeptide, or a nucleic acid encoding said p97 adhesin adjuvant polypeptide, and a heterologous antigen are disclosed. Uses of the p97 adhesin adjuvant polypeptide or nucleic acid, or immunogenic compositions comprising same, for inducing an immune response against a heterologous antigen in a subject are also disclosed.

主权项

1. An immunogenic composition comprising a p97 adhesin adjuvant polypeptide comprising a sequence having at least 80% sequence identity with the amino acid sequence of SEQ ID NO: 9 and having adjuvant properties, covalently linked to a heterologous antigen polypeptide.