Soluble PD-1 variants, fusion constructs, and uses thereof

摘要

The subject invention provides novel soluble PD-1 (sPD-1) proteins, nucleic acids, and fusion constructs thereof, for enhancing humoral and cell-mediated immunity of a subject. Also provided are therapeutic compositions comprising the sPD-1 proteins, nucleic acids, and fusion constructs of the subject invention. In a preferred embodiment, the therapeutic composition is formulated as a vaccine composition. Advantageously, the sPD-1 proteins, nucleic acids, and therapeutic compositions provide protective immunity against pathogenic infection including HIV infection. In addition, the subject invention can be used in the prevention and/or treatment of tumor or cancer.

主权项

1. A PD-1 DNA molecule encoding a soluble PD-1 protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 11, SEQ ID NO: 15, and SEQ ID NO: 25.