| 主权项 |
1. A compound of the formula I wherein: R1 is selected from (C5-C16)-alkyl, Y-aryl, and Y-heteroaryl,
wherein aryl is substituted one or more times by groups selected from OH, CF3, NO2, CN, OCF3, O—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, S—(C1-C6)-alkyl, CH2CH3, —CH2—CH2—CH2—CH3, (C2-C4)-haloalkyl, O—(C2-C4)-haloalkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O—(C3-C8)-cycloalkyl, (C2-C6)-alkynyl, (C0-C8)-alkylene-aryl, O—(C0-C8)-alkylene-aryl, S-aryl, (C0-C8)-alkylene-heteroaryl, N(R4)(R5), SO2—CH3, SO2—NH2, SF5, COOH, COO—(C1-C6)-alkyl, CON(R6)(R7), N(R8)CO(R9), N(R10)SO2(R11), CO(R12), (CR13R14)x—O(R15), O—CO—N(R16)(R17), O—CO—(C1-C6)-alkylene-CO—O—(C1-C6)-alkyl, O—CO—(C1-C6)-alkylene-CO—OH, and O—CO—(C1-C6)-alkylene-CO—N(R18)(R19), wherein heteroaryl in Y-heteroaryl is optionally substituted one or more times by the aforesaid groups, wherein aryl or heteroaryl in the aforesaid groups is optionally substituted one or more times by groups selected from F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, S—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C4)-haloalkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O—(C3-C8)-cycloalkyl, (C2-C6)-alkynyl, N(R4a)(R5a), SO2—CH3, SF5, COOH, COO—(C1-C6)-alkyl, CON(R6a)(R7a), N(R8a)CO(R9a), N(R10a)SO2(R11a), CO(R12a), (CR13aR14a)x′-O(R15a), O—CO—N(R16a)(R17a), O—CO—(C1-C6)-alkylene-CO—O—(C1-C6)-alkyl, O—CO—(C1-C6)-alkylene-CO—OH, and O—CO—(C1-C6)-alkylene-CO—N(R18a)(R19a); x, x′ are selected from 0, 1, 2, 3, 4, 5, and 6; R4, R5, R6, R7, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R4a, R5a, R6a, R7a, R9a, R10a, R11a, R12a, R13a, R14a, R15a, R16a, R17a, R18a, and R19a are independently selected from hydrogen, (C1-C8)-alkyl, and a radical of the formula Ia wherein W is selected from —C(R26)(R27)-, —C(R26)(R27)-C(R28)(R29)-, and —C(R26)(R27)-O; R20, R21, R22, R23, R24, R25, R26, R27, R28, R29 are independently selected from
F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, SF5, O—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, S—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C4)-haloalkyl, O—(C2-C4)-haloalkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O—(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, (C2-C6)-alkynyl, N(R30)(R31), SO2—CH3, COOH, COO—(C1-C6)-alkyl, CON(R32)(R33), N(R34)CO(R35), N(R36)SO2(R37), CO(R38), (CR39R40)x″, —O(R41), O—CO—N(R42)(R43), O—CO—(C1-C6)-alkylene-CO—O—(C1-C6)-alkyl, O—CO—(C1-C6)-alkylene-CO—OH, and O—CO—(C1-C6)-alkylene-CO—N(R44)(R45); x″ is selected from 0, 1, 2, 3, 4, 5, and 6; R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, R42, R43, R44, and R45 are independently selected from hydrogen and (C1-C6)-alkyl; or R20 and R26, or R21 and R27, together with the carbon atoms carrying them, form a monocyclic, 5- or 6-membered saturated, partly unsaturated, or aromatic ring system whose individual members may be replaced by —CHR46-, —CR46R47-, or ═(C—R46)-; or R22 and R24, or R23 and R25, together with the carbon atoms carrying them, form a monocyclic, 5- or 6-membered saturated, partly unsaturated, or an aromatic ring system whose individual members may be replaced by —CHR46-, —CR46R47-, or ═(C—R46)-; R46 and R47 are independently selected from F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, SF5, O—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, S—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C4)-haloalkyl, O—(C2-C4)-haloalkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O—(C3-C8)-cycloalkyl, (C2-C6)-alkynyl, N(R48)(R49), SO2—CH3, COOH, COO—(C1-C6)-alkyl, CON(R50)(R51), N(R52)CO(R53), N(R54)SO2(R55), CO(R56), (CR57R58)x′″, —O(R59), O—CO—N(R60)(R61), O—CO—(C1-C6)-alkylene-CO—O—(C1-C6)-alkyl, O—CO—(C1-C6)-alkylene-CO—OH, and O—CO—(C1-C6)-alylene-CO—N(R62)(R63); x′″ is selected from 0, 1, 2, 3, 4, 5, and 6; R48, R49, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, and R63 are independently selected from hydrogen and (C1-C6)-alkyl; Y and Z are independently selected from (C1-C2)-alkylene, which is optionally substituted once by F, Cl, CH3 or OH; R2 is selected from hydrogen, (C1-C12)-alkyl and Z-aryl, wherein aryl is optionally substituted by (C3-C12)-cycloalkyl; R3 is selected from (C1-C12)-alkyl, aryl, and heteroaryl, wherein aryl or heteroaryl is optionally substituted by (C3-C12)-cycloalkyl; or R2 and R3, together with the carbon atoms carrying them, form a monocyclic, saturated, or partly unsaturated 4- to 8-membered ring system whose individual members may be replaced by one to three atoms or atomic groups selected from —CHR64-, —CR64R65-, ═(C—R66)-, —NR67-, —C(═O)—, and —O—, with the proviso that two units from the series —O— may not be adjacent; R64, R65, R66, and R67 are independently selected from hydrogen, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, SF5, O—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, S—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C4)-haloalkyl, O—(C2-C4)-haloalkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O—(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, (C2-C6)-alkynyl, N(R68)(R69), SO2—CH3, COOH, COO—(C1-C6)-alkyl, CON(R70)(R71), N(R72)CO(R73), N(R74)SO2(R75), CO(R76), (CR77R78)x″″—O(R79), O—CO—N(R80)(R81), O—CO—(C1-C6)-alkylene-CO—O—(C1-C6)-alkyl, O—CO—(C1-C6)-alkylene-CO—OH, and O—CO—(C1-C6)-alkylene-CO—N(R82)(R83); x″″ is selected from 0, 1, 2, 3, 4, 5, and 6; R68, R69, R70, R71, R72, R73, R74, R75, R76, R77, R78, R79, R80, R81, R82, and R83 are independently selected from hydrogen and (C1-C6)-alkyl; with the proviso that the compound with R1=cyclohexyl, R2=H, and R3=phenyl is excluded; including tautomeric forms of the compound and their physiologically tolerated salts. |
