| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to nanoaggregates of water-soluble fullerene derivatives, which can be used for reducing toxicity and enhancing therapeutic action of drugs for oncologic diseases. There are presented nanoaggregates of water-soluble fullerene derivatives of general formulawherein k=3-1,000,000,000; wherein the values i, l, m, X and R are described by the following formulas: i=30, m=5, X=H, l=1, while R is a residue of thioic acid of formula -S(CH)COOH, n=2 in the form of potassium salt; i=30, m=5, a X=H, l=1, R is a phosphonate residue of P(O)(OR) (OR) (OR), wherein R, R,Rare ethyl radical; i=30, m=5, X=Cl, l=1, while R is an aryl residue of formula -CH(CH)COOH, wherein n=3, which can be presented in the form of potassium salt; i=35, m=8, l=0, while R is an aryl residue of formula -CH(CH)COOH, wherein n=2, in the form of potassium salt.EFFECT: there are presented new nanoaggregates, which can be effective in treating the oncologic diseases.2 cl, 9 ex, 1 tbl, 11 dwg |
