| 摘要 |
Compounds of the formula (I) wherein R2, A are certain substituents, Y is an ester group, a nitrile group or an amido group and Z is O, S or N′R2, and which compounds are, for example, useful as intermediates for pyrazole fungicides, can be prepared by the reaction of a compound of formula R2—C(O)—CH2Y, with an orthoformate HC—(OR3)3 in the presence of a base, especially in the presence of an amine, e.g. triethylamine; |
| 主权项 |
1. A method for the manufacture of a compound of formula (I)by the reaction of the method comprising: reacting a compound of formula (II), R2—C(O)—CH2Y, with an orthoformate of formula (III), HC—(OR3)3 in the presence of a base wherein
R2 is selected from C1 to C4 alkyl groups are substituted by one, two or three halogen atoms selected from the group consisting of F, Cl and Br or a CF3 group; R3 is C1 to C8 alkyl; C3 to C8 cycloalkyl; C2 to C8 alkenyl; benzyl or phenyl; C1 to C8 alkyl, C3 to C8 cycloalkyl, C2 to C8 alkenyl, benzyl or phenyl substituted by one or more groups selected from the group consisting of R′, X, OR′, SR′, NR′2, SiR′3, COOR′, C(O)R′, CN and CONR′2 wherein R′ is H or a C1 to C12 group, and X is fluorine, chlorine, bromine and iodine; Y is selected from the group consisting of C(O)OR4, CN and C(O)NR5R6 wherein R4, R5 and R6 are independently of each other are selected from the group consisting of C1 to C12 alkyl; C3 to C8 cycloalkyl; C2 to C12 alkenyl; C2 to C12 alkynyl; C6 to C8 aryl; C7 to C19 arylalkyl; and C7 to C 19 alkylaryl; each of which may be substituted by one or more groups selected from the group consisting of R′, X, OR′, SR′, NR′2, SiR′3, COOR′, C(O)R′, CN and CONR′2 wherein R′ is H or a C1 to C12 group; and R5 and R6 together with the nitrogen atom to which they are attached may form a 5-membered or 6-membered ring which may optionally contain one or more further heteroatoms selected from the group consisting of O, S and an SO2 group and which may be substituted by one or more groups selected from the group consisting of R′, X, OR′, SR′, NR′2, SiR′3, COOR′, C(O)R′, CN and CONR′2 wherein R′ is H or a C1 to C12 group; and X is fluorine, chlorine, bromine and iodine; A is OR3 wherein R3 has the meaning given above; Z is selected from the group consisting of O, S and N+R7R8 wherein R7 and R8 independently from each other are selected from the group consisting of C1 to C12 alkyl; C3 to C8 cycloalkyl; C2 to C12 alkenyl; C2 to C12 alkynyl; C6 to C8 aryl; C7 to C19 arylalkyl; and C7 to C19 alkylaryl; each of which may be substituted by one or more groups selected from the group consisting of R′, X, OR′, SR′, NR′2, SiR′3, COOR′, C(O)R′, CN and CONR′2 wherein R′ is H or a C1 to C12 group; and R7 and R8 together with the nitrogen atom to which they are attached may form a 5-membered or 6-membered ring which may optionally contain one or more further heteroatoms selected from the group consisting of O, S and an SO2 group and which may be substituted by one or more groups selected from the group consisting of R′, X, OR′, SR′, NR′2, SiR′3, COOR′, C(O)R′, CN and CONR′2 wherein R′ is H or a C1 to C12 group; and X is fluorine, chlorine, bromine and iodine; and when Z is N+R7R8 the positive charge is balanced by an anion. |
