METHOD FOR PRODUCING STEREOSELECTIVE EPOXYKETONE COMPOUND

摘要

A novel method for producing a stereoselective epoxyketone compound is provided. A method for producing an epoxyketone compound represented by the formula (1), as represented by the following scheme, whereby it is possible to obtain an epoxyketone derivative in good yield and at high selectivity and to provide an industrially useful production method and an intermediate thereof. wherein R1 is a hydrogen atom, a linear, branched or cyclic alkyl group, an aromatic group which may have a substituent, or a heterocyclic group which may have a substituent, and R2 is a protective group for an amino group. R is a hydrogen atom or a C1-10 alkyl group, and R's may be the same or different, provided that at least one R is a C1-10 alkyl group.;

主权项

1. A method for producing an alcohol compound of formula (3): the method comprising: reducing a compound of formula (2): in the presence of an amine borane complex of R3N.BH3, wherein R1is a hydrogen atom, a linear, branched or cyclic alkyl group, an aromatic group which optionally has a substituent, or a heterocyclic group which optionally has a substituent, R2 is a protective group for an amino group, and each R is independently a hydrogen atom or a C1-10 alkyl group, provided that at least one R is a C1-10 alkyl group.