PROCESS FOR PRODUCING DERIVATIVES OF PYROSTEGIA VENUSTA, DERIVATIVES OF PYROSTEGIA VENUSTA, PHARMACEUTICAL COMPOSITIONS AND ITS USES

摘要

The present invention relates to the process for producing compounds derived from the plant Pyrostegia venusta (P. venusta), pharmaceutical compositions comprising the same and its medical uses, especially as antimicrobial.

主权项

1. A process for producing derivatives of P. venusta, comprising the basic steps of:
a) cold-maceration of fresh leaves of P. venusta with a solution of ethanol/water, b) filtration and concentration, c) dehydration to provide a dry extract, d) solubilization of the dry extract in methanol/water e) division of the solution methanol/water in hexane, to provide a an aqueous fraction PV1 and a hexanic fraction PV2, f) division of the aqueous fraction PV1 with solution water/ethyl acetate, achieving an aqueous fraction PV4 and an acetate fraction PV3, g) division of the aqueous fraction PV4 with solution water/n-butanol, achieving an aqueous fraction PV5 and a n-butanol fraction PV6, and h) gathering of the n-butanol fraction PV6. i) standardization of the n-butanol fraction PV6 by HPLC, from the standard curve.