| 发明名称 |
ANTI-TUMOR ENDOTHELIAL MARKER-1 (TEM1) ANTIBODY VARIANTS AND USES THEREOF |
| 摘要 |
The invention relates to variants of an antibody or antigen-binding fragment that binds specifically to an endosialin tumor endothelial marker 1 (TEM1), and prophylactic, diagnostic, and therapeutic methods using the same. |
| 申请公布号 |
US2015125385(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201314397128 |
申请日期 |
2013.03.15 |
| 申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Coukos George;Li Chunsheng |
| 分类号 |
C07K16/28;G01N33/574;A61K45/06;A61K39/395;A61K51/10 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An anti-tumor endothelial marker-1 (TEM1) antibody dimer or an anti-TEM1 antigen-binding fragment dimer comprising, a dimer of an anti-TEM1 antibody or antigen-binding fragment linked to a hinge, wherein said antibody or antigen-binding fragment is dimerized using said hinge. |
| 地址 |
Philadelphia PA US |
