METHOD OF DETECTING PLATELET ACTIVATING ANTIBODIES THAT CAUSE HEPARIN-INDUCED THROMBOCYTOPENIA/THROMBOSIS
摘要
The present invention provides a method of detecting platelet activation in a patient, the method comprising the steps of a) obtaining a blood sample from a patient suspected of having heparin-induced thrombocytopenia (HIT); b) incubating an effective amount of platelet factor 4 (PF4) with a sample of platelets to yield a sample of PF4-treated platelets; c) contacting the patient blood sample with the PF4-treated platelets; and d) measuring the extent of platelet activation, wherein an increase in platelet activation compared with results obtained using a normal blood sample is indicative of the patient having HIT.
申请公布号
WO2015065986(A1)
申请公布日期
2015.05.07
申请号
WO2014US62591
申请日期
2014.10.28
申请人
BLOODCENTER RESEARCH FOUNDATION;ASTER, RICHARD, H.;BOUGIE, DANIEL, W.;JONES, CURTIS, GERALD;PADMANABHAN, ANAND