发明名称 |
METHOD OF DETECTING PLATELET ACTIVATING ANTIBODIES THAT CAUSE HEPARIN-INDUCED THROMBOCYTOPENIA/THROMBOSIS |
摘要 |
The present invention provides a method of detecting platelet activation in a patient, the method comprising the steps of a) obtaining a blood sample from a patient suspected of having heparin-induced thrombocytopenia (HIT); b) incubating an effective amount of platelet factor 4 (PF4) with a sample of platelets to yield a sample of PF4-treated platelets; c) contacting the patient blood sample with the PF4-treated platelets; and d) measuring the extent of platelet activation, wherein an increase in platelet activation compared with results obtained using a normal blood sample is indicative of the patient having HIT. |
申请公布号 |
CA2928822(A1) |
申请公布日期 |
2015.05.07 |
申请号 |
CA20142928822 |
申请日期 |
2014.10.28 |
申请人 |
BLOODCENTER RESEARCH FOUNDATION |
发明人 |
ASTER, RICHARD H.;BOUGIE, DANIEL W.;JONES, CURTIS GERALD;PADMANABHAN, ANAND |
分类号 |
G01N33/86;C12Q1/56;G01N33/48;G01N33/50;G01N33/53;G01N33/88 |
主分类号 |
G01N33/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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