COMBINATION THERAPY FOR TREATING HEARING AND BALANCE DISORDERS

摘要

The present application relates to combinations of inhibitors directed at down-regulation of genes associated with hearing loss including HES1, HES5, HEY2, CDKN1B and NOTCH1, exhibiting a beneficial effect and useful in treating or attenuating hearing loss, treating balance impairment, promoting the replacement, regeneration, or protection of otic (sensory) hair cells of the inner ear, and or effecting hearing restoration/regeneration.

主权项

1. A combination of a HES1 inhibitor, a HES5 inhibitor and a HEY2 inhibitor, for simultaneous, separate or sequential use in a subject for preventing, treating, or delaying of progression of a hearing disorder, a hearing loss, and/or a balance impairment, or for preventing the loss of otic (sensory) hair cells of the inner ear in the subject.