METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS

摘要

The present invention relates to a method and kit for the classification and prognosis of wounds of mammalian, in particular in human. The method defines a molecular signature that enables one to characterize a pathological wound healing such as chronic or non-healing wound.

主权项

1. A method of diagnosis or prognosis of a non-healing or chronic wound tissue comprising the step of determining the levels of expression of genes encoding different molecular markers in a sample of a wound from a mammalian, wherein:
at least one of the following genes shows increased expression when compared with the expression in normal dermal fibroblasts of said mammalian:POU2F2, AMIGO2, CCL11, CDC45L, CSF2, CSF3, FOXS1, GOS2, IF44L, INHBA, KPRP, LCP1, LPAR3, MICAL2, MT1F, MT1M, POLQ, RRM2, SERPINA9, SOX9, STC1, TFIP2 and UCN2,
or at least the following miRNA shows decreased expression when compared with the expression in normal dermal fibroblasts of said mammalian:AC084368.1,
or at least one of the following genes shows a normal expression when compared with the expression in normal dermal fibroblasts of said mammalian:CNN1 and KRT16,
or at least one of the following genes shows decreased expression when compared with the expression in normal dermal fibroblasts of said mammalian:ACTC1, ADAMTS7, CFB, COMP, ECM2, EDIL3, EFHD1, FOLR1, ITGA11, KIT, LBH, LGR5, MED12L, MFAP5, NR4A3, OMD, PALM, PHACTR3, PI16, PPARG, PTH1R, PTX3, RCAN2, RSPO1, SPON2, TAGLN, TMEM37, TMSB4Y, TXNIP and WFDC1,
or at least one of the following miRNA shows increased expression when compared with the expression in normal dermal fibroblasts of said mammalian:MIR147B and MIR1181.