HYPERMETHYLATED GENE MARKERS FOR HEAD AND NECK CANCER

摘要

Methods and kits for diagnosing or predicting head and neck squamous cell carcinoma (HNSCC) and for predicting responsivity to therapeutic regimens for treating HNSCC are disclosed.

主权项

1. A method for diagnosing or predicting head and neck squamous cell carcinoma (HNSCC) in a subject having or at risk of developing HNSCC, the method comprising:
(a) obtaining a sample from the subject; (b) determining the methylation state of a regulatory region of a gene in the sample, wherein the gene is selected from the group consisting of ZNF14, ZNF160, and ZNF420; and (c) comparing the methylation state of the regulatory region of the gene in the sample to the methylation state of the regulatory region of the gene in a control sample; wherein hypermethylation of the regulatory region of the gene in the sample as compared to the regulatory region of the gene in the control sample is indicative that the subject has or is at risk of developing HNSCC.