发明名称 |
MICRORNAS MODULATING THE EFFECT OF GLUCOCORTICOID SIGNALING |
摘要 |
The present invention discloses microRNAs (miR) involved in the regulation of the lipid and glucose metabolism. Several conserved miR molecules were found as direct targets of the glucocorticoid hormone / glucocorticoid receptor signaling axis. Hence, the present invention pertains to inhibitors of these miRs - such as antimiRs and blockmiRs - as well as isolated miR molecules or miR expression constructs for the treatment or prevention of metabolic disorders caused by deregulated glucocorticoid signaling, such as insulin resistance, the metabolic syndrome, obesity and/or diabetes type II. Particular preferred embodiments of the invention pertain to antagonists or agonists of a miR of the conserved miR-379-410 cluster, particularly of miR-379. |
申请公布号 |
WO2015063081(A2) |
申请公布日期 |
2015.05.07 |
申请号 |
WO2014EP73115 |
申请日期 |
2014.10.28 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS;RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG |
发明人 |
BERRIEL DIAZ, MAURICIO;DE GUIA, ROLDAN;HERZIG, STEPHAN |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
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