发明名称 |
Amphiphilic block copolymer and preparation method thereof and micellar drug-loading system formed by same with antitumor drug |
摘要 |
The present invention relates to an new type amphiphilic block copolymer and preparation method thereof, and a micellar drug-loading system formed by the copolymer with an antitumor drug. The amphiphilic block copolymer comprises an amphiphilic chain segment and a hydrophobic chain segment, wherein the end-group of the hydrophobic chain segment is blocked with a hydrophobic group. The amphiphilic block copolymer of the present invention employs a polyethylene glycol monoethylether (or polyethylene glycol)-polyester block copolymer with a recognized safety as a base material and the end-hydroxy of the polyester chain segment is modified with a hydrophobic group, which not only improves the compatibility of the drug molecule with the hydrophobic chain segment of the block copolymer and increases the force therebetween, but also provides a bigger space for accommodating the drug molecule; the prepared micelle can more effectively confine the drug molecule in the core of the micelle so that the drug molecule does not dissolve easily, thus the drug-loading micelle with high stability is obtained. |
申请公布号 |
AU2013334301(A1) |
申请公布日期 |
2015.05.07 |
申请号 |
AU20130334301 |
申请日期 |
2013.09.22 |
申请人 |
SUZHOU NANOMEDICINE R&D CO., LTD. |
发明人 |
LIU, KE;GONG, FEIRONG;XU, HUI;LANG, YUEWU;FAN, HUAYING;HAN, FEI;CHE, XIN |
分类号 |
C08G63/91;A61K9/00;A61K9/19;A61K47/34;A61K47/42;A61P35/00;C08G63/08 |
主分类号 |
C08G63/91 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|