| 摘要 |
<p>The present invention relates to methods for inhibiting tumor growth or improving tolerability to at least one chemotherapeutic agent. The method comprises: (i) administering to a subject in need thereof an effective amount of a humanized monoclonal antibody or a functional fragment thereof, wherein the antibody or the fragment thereof has at least one complementarity determining region of murine monoclonal antibody BAT (mBAT-1) and a framework region (FR) from an acceptor human immunoglobulin, or modified therefrom; and (ii) administering to the subject an effective amount of at least one chemotherapeutic agent selected from the group consisting of an antimetabolite, a platinum-based agent and a mitotic inhibitor, wherein the humanized antibody is administered between 1 and 30 days before commencing chemotherapy, between 1 and 30 days after commencing chemotherapy, or according to an alternating schedule with the at least one chemotherapeutic agent; thereby treating the tumor or enhancing survival of the subject having the tumor. 40 -4 hBAT-1 (pg/ml) Time (hr) 60 -1 Time (hr)</p> |
