BIOMATERIALS FOR ENHANCED IMPLANT-HOST INTEGRATION

摘要

The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure is provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.

主权项

1. A patterned biomaterial comprising:
a naturally-derived or synthetic scaffolding; and
(a) at least one cord, wherein the cord is at least partially embedded in the scaffold in a spatially delineated form and is comprised of at least one cell type; or(b) at least one cluster of cells, wherein the cluster of cells is at least partially embedded in the scaffold in a spatially delineated form and is comprised of at least one cell type.