发明名称 METHODS AND INTERMEDIATES FOR THE PREPARATION OF FONDAPARINUX
摘要 The present invention relates to methods for the synthesis of fondaparinux and intermediates thereto.
申请公布号 US2015126721(A1) 申请公布日期 2015.05.07
申请号 US201314406074 申请日期 2013.06.03
申请人 Academia Sinica 发明人 Hung Shang-Cheng;Chang Cheng-Hsiu
分类号 C07H15/04;C07H1/00;C07H23/00 主分类号 C07H15/04
代理机构 代理人
主权项 1. A compound of Formula (I):wherein: X1 is —ORA or —SRA, wherein RA is hydrogen, an oxygen or sulfur protecting group, optionally substituted C1-10 alkyl, optionally substituted aryl, optionally substituted acyl, or optionally substituted imidoyl; R2 and R11 are independently optionally substituted arylalkyl; RN1, RN2, and RN3 are independently —N3 or —N(RW)2, wherein each RW is independently hydrogen or a nitrogen protecting group; R3 and R6 are independently —C(O)RD, wherein each occurrence of RD is independently optionally substituted alkyl or optionally substituted aryl; R1, R5, and R9 are independently selected from the group consisting of optionally substituted arylalkyl and —Si(RB)3, wherein each RB is independently alkyl or aryl; R10 is optionally substituted arylalkyl; RY and RZ are independently hydrogen or an oxygen protecting group; R7 is selected from the group consisting of —Si(RB)3, optionally substituted arylalkyl, and —C(O)RC, wherein RC is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl; and R4 and R8 are independently optionally substituted arylalkyl; or a salt thereof.
地址 Taipei TW
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