SOLID ORAL MODIFIED-RELEASE COMPOSITION COMPRISING OXCARBAZEPINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

摘要

The present invention relates to solid oral modified-release composition comprising oxcarbazepine or salts thereof. In particular, the present invention relates to solid oral modified-release compositions comprising a core of oxcarbazepine or a pharmaceutically acceptable salt thereof coated with a functional coating. Preferably, the composition comprises a matrix core coated with one or more functional coatings comprising one or more rate-controlling excipients having pH-dependent solubility, which core is devoid of excipients having pH dependent solubility. The invention further relates to process of preparing said pharmaceutical composition and their use in treatment of epileptic seizures.