| 摘要 |
<p>[Object] To provide a method for accurately determining cerebral blood flows both in rest state and under medication with less invasive operations. [Solution] Cerebral blood flow is determined based on a formula represented by the following formulas (1) or (2) for a time under medication that continuously follows a resting time. B t = k 1 �¢ e - k 2 �¢ t 3 �¢ m �¢ C f ˆ« t 0 t 3 S Ä �¢ e k 2 �¢ Ä † Ä �¢ e - k 2 �¢ d �¢ t - t 3 + k 1 �¢ d �¢ m �¢ C f �¢ ˆ« t 3 t �¢ S Ä + S �¢ Ä - t 3 ‹ e - k 2 �¢ d ‹ t - Ä † Ä t ‰¥ t 3 ˆ« t 5 t 6 B t † t = k 1 k 2 �¢ d �¢ e - k 2 �¢ t 3 �¢ m �¢ C f ˆ« t 0 t 3 S Ä �¢ e k 2 �¢ Ä † Ä ‹ e - k 2 �¢ d �¢ t 5 - t 3 - e - k 2 �¢ d �¢ t 6 - t 3 + ˆ« t 5 t 6 k 1 �¢ d �¢ m �¢ C f ˆ« t 3 t S Ä + S �¢ Ä - t 3 ‹ e - k 2 �¢ d ‹ t - Ä † Ä �¢ dt t ‰¥ t 3 (B(t): the radiation count at the time of t, t 3 : the time when a radioisotope medicine is administered, t 5 : the time when acquisition of the imaging data started for the state under medication, t 6 : the time when acquisition of the imaging data finished for the state under medication, mC f : a scaling factor, k 1 : cerebral blood flow rest state, k 2 : the blood-outflow-rate-constant of brain tissues rest state, k 1d : a cerebral blood flow under medication, and k 2d : the blood-outflow-rate-constant of brain tissues under medication)</p> |
