CANNABIS PLANT ISOLATE COMPRISING DELTA-9-TETRAHYDROCANNABINOL AND A METHOD FOR PREPARING SUCH AN ISOLATE

摘要

The present invention relates to a method for preparing a Cannabis plant Δ9-tetrahydrocannabinol isolate from a crude solvent extract of Cannabis plant material. The invention relates further to a Cannabis plant THC isolate comprising Δ9-tetrahydrocannabinol, Cannabinol (CBN) and/or Cannabidiol (CBD) and to a pharmaceutical composition comprising the Cannabis plant THC isolate.

主权项

1. A method for preparing a Cannabis plant Δ9-tetrahydrocannabinol (THC) isolate from a crude solvent extract of Cannabis plant material, comprising:
a) subjecting a crude solvent extract of Cannabis plant material containing, by weight of dry matter, 20-90% THC, 0.1-2.0% Cannabinol (CBN) and 0.1-1.0% Cannabidiol (CBD) to thin film evaporation to obtain a refined extract; b) chromatographically fractionating the refined extract to produce one or more high purity fractions having a THC content higher than a preset value and one or more low purity fractions having a THC content lower than said preset value, wherein the preset value is in the range of 95-99% by weight of dry matter; c) subjecting the one or more high purity fractions to another thin film evaporation; and d) collecting a THC isolate containing at least 97% THC by weight of dry matter; and wherein in step a) and/or in step c) the thin film evaporation is carried out by wiped film evaporation.