| 主权项 |
1. A method for producing a contrast agent containing a conjugate of a compound expressed by general formula (I) and a compound expressed by general formula (II), the method comprising:
the reaction step of allowing the compound expressed by general formula (I) to react with the compound expressed by general formula (II) to form the conjugate, and the purification step of purifying the conjugate using an organic solvent,wherein general formula (I) is: wherein R101 to R112 each represent a species selected from the group consisting of hydrogen and linear and branched alkyl groups having a carbon number in the range of 1 to 18, L11 to L17 each represent a group selected from the group consisting of CH and CR15 and may form one of 4-membered to 6-membered rings, R15 represents an alkyl group selected from the group consisting of linear and branched alkyl groups having a carbon number in the range of 1 to 18, R11 to R14 each represent a species selected from the group consisting of hydrogen and linear and branched alkyl groups having a carbon number in the range of 1 to 18, A11 and B11 each represent an alkylene group selected from the group consisting of linear and branched alkylene groups having a carbon number in the range of 1 to 18, and Ra represents an atom selected from the group consisting of hydrogen, sodium and potassium, and wherein general formula (II) is: wherein D11 represents an alkylene group selected from the group consisting of linear and branched alkylene groups having a carbon number in the range of 1 to 18, E11 represents a species selected from the group consisting of hydrogen, linear and branched alkoxy groups having a carbon number in the range of 1 to 18, and linear and branched alkyl groups having a carbon number in the range of 1 to 18, m represents an integer in the range of 1 to 20, and n represents an integer in the range of 1 to 2,500. |
