| 发明名称 |
COMPOSITION AND METHOD FOR TREATING NEUROLOGICAL DISEASE |
| 摘要 |
Disclosed are compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of amantadine. Methods of administering the same are also provided. |
| 申请公布号 |
US2015126612(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201514591662 |
申请日期 |
2015.01.07 |
| 申请人 |
Adamas Pharmaceuticals, Inc. |
发明人 |
Went Gregory T.;Fultz Timothy J. |
| 分类号 |
A61K31/13;A61K9/00 |
主分类号 |
A61K31/13 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition suitable for once daily oral administration to a human subject consisting of
(i) 50 to 500 mg of a drug selected from the group consisting of amantadine and pharmaceutically acceptable salts thereof, and (ii) at least one excipient,wherein at least 50% of the drug in the composition is in an extended release form, andwherein the composition has an in vitro dissolution profile ranging between 35% and 55% in 2 hours, 60% and 80% in 4 hours, and greater than 90% in 8 hours using a USP type 2 (paddle) dissolution system at 50 rpm at a temperature of 37±0.5° C. in water. |
| 地址 |
Emeryville CA US |
