| 发明名称 |
MicroRNAs and Uses Thereof |
| 摘要 |
Provided herein are methods for inhibiting expression of DOHH in a cell, and for inhibiting hypusination of eIF5A in a cell, the methods comprising contacting a cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3′UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation. |
| 申请公布号 |
US2015126581(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201314383704 |
申请日期 |
2013.03.08 |
| 申请人 |
The University of Western Australia |
发明人 |
Leedman Peter;Giles Keith;Epis Michael;Barker Andrew |
| 分类号 |
C12N15/113;A61K45/06;C12Q1/68;A61K31/7088 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting expression of deoxyhypusine hydroxylase monooxygenase (DOHH) in a cell, comprising contacting the cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3′UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. |
| 地址 |
Perth, Western Australia AU |
