摘要 |
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2- heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders. |
申请人 |
MIDWESTERN UNIVERSITY;RHODE ISLAND HOSPITAL |
发明人 |
WANDS, JACK R.;DE LA MONTE, SUZANNE;AIHARA, ARIHIRO;OLSEN, MARK JON;THOMAS, JOHN-MICHAEL |