| 发明名称 |
IL-6 ANTAGONISTS AND USES THEREOF |
| 摘要 |
IL-6 antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases, e.g., disease of the eye such as diabetic macular edema are disclosed. |
| 申请公布号 |
US2015125468(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201414508068 |
申请日期 |
2014.10.07 |
| 申请人 |
ELEVEN BIOTHERAPEUTICS, INC. |
发明人 |
Schmidt Michael March;Barnes Thomas M.;Erbe David V.;Furfine Eric Steven;Tisdale Alison |
| 分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody or antigen binding fragment thereof comprising
a. a VH CDR1 as set forth in SEQ ID NO:4, a VH CDR2 as set forth in SEQ ID NO:5, and VH CDR3 as set forth in SEQ ID NO:6; and b. a VL CDR1 as set forth in SEQ ID NO:7, a VL CDR2 as set forth in SEQ ID NO:8, and a VL CDR3 as set forth in SEQ ID NO:9. |
| 地址 |
Cambridge MA US |
