发明名称 |
MODULATION OF SPHINGOSINE 1-PHOSPHATE METABOLIZING ENZYMES FOR THE TREATMENT OF NEGATIVE-STRAND RNA VIRUS INFECTIONS |
摘要 |
The present invention relates to compounds and methods for the prevention or treatment of infections by negative strand RNA viruses, such as influenza virus and measles virus, wherein said compounds delay or inhibit viral replication by modulating the level or activity of a polypeptide involved in the synthesis or degradation of sphingosine-1-phosphate (S1P) in a cell, tissue, or subject. The methods involve administration of one or more compounds which modulate the level of gene expression, where the gene encodes a polypeptide involved in regulating the metabolic level of S1P, or modulate the level or activity of a polypeptide involved in regulating the metabolic level of S1P, such as sphingosine kinase (SK) and S1P lyase (SPL). Exemplary methods are directed towards reducing the level of SW by reducing the level or activity of one or more SKs, increasing the level or activity of one or more SPLs, or a combination of both steps. |
申请公布号 |
US2015126564(A1) |
申请公布日期 |
2015.05.07 |
申请号 |
US201214122399 |
申请日期 |
2012.05.31 |
申请人 |
THE CURATORS OF THE UNIVERSITY OF MISSOURI |
发明人 |
Hahm Bumsuk;Seo Young-Jin;Alexander Stephen;Madhuvanthi Vijayan |
分类号 |
A61K31/426;A61K31/133 |
主分类号 |
A61K31/426 |
代理机构 |
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代理人 |
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主权项 |
1. A method of modulating the infection, replication, assembly, or release of a negative-strand RNA virus in a eukaryotic cell, comprising administering one or more agents which modulate the level or activity of a protein involved in the synthesis or degradation of sphingosine-1-phosphate in said cell. |
地址 |
COLUMBIA MO US |