发明名称 |
PRODUCTION OF STERILE LIPOSOMES OF ANY PARTICLE SIZES BY CONTINUOUS EXTRUSION IN A CLOSED SYSTEM |
摘要 |
<p>A process for producing liposomes in a way that the size of the liposomes is achieved by passing the preformed MLV dispersion through a membrane with adequate pore size into another container and then recirculating it back to the same container through the membrane until adequate particle size is reached. The modus of the size distribution of the particles can be arbitrary set to at least 5% preciosity depending on the diameter of the applied pores and circulating time. Using sterile or sterile filtered ingredients and equipment that has all of its parts sterilized and due to the closed production technology the process is aseptic, thus the produced liposome product is sterile.</p> |
申请公布号 |
WO2015063710(A1) |
申请公布日期 |
2015.05.07 |
申请号 |
WO2014IB65701 |
申请日期 |
2014.10.30 |
申请人 |
RICHTER GEDEON NYRT. |
发明人 |
LÁZÁR, JÓZSEF;KOVÁCS-KISS, DOROTTYA;GÁLOS, ZOLTÁN |
分类号 |
A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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