发明名称 |
TREATMENT OF EGF-RECEPTOR DEPENDENT PATHOLOGIES |
摘要 |
<p>Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent ("First Agent") that decreases the biological activity of iRhoml and an effective amount of an agent ("Second Agent") that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent ("First Agent") that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent ("Second Agent") that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents.</p> |
申请公布号 |
WO2014100602(A8) |
申请公布日期 |
2015.05.07 |
申请号 |
WO2013US76954 |
申请日期 |
2013.12.20 |
申请人 |
HOSPITAL FOR SPECIAL SURGERY;UNIVERSITY HEALTH NETWORK |
发明人 |
BLOBEL, CARL;MARETZKY, THORSTEN;MCILWAIN, DAVID;MAK, TAK, WAH |
分类号 |
C12N15/113;A01K67/027;C07K16/18 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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