Biodegradable Layer-by-Layer (LbL) Films for Cell Capture and Release

摘要

Compositions and methods for providing devices comprised of a substrate and a Layer-By-Layer (LBL) film coated on at least a surface of the substrate, which LBL film comprises binding agents that specifically interact with cells. Such devices are useful, for example, in various cell isolation applications. Among other advantages, such devices permit isolation and release (e.g., via layer degradation) of cells under mild conditions.

主权项

1. A device, comprising:
a substrate having a surface; and a layer-by-layer (LbL) film disposed on said surface, the LbL film comprising at least one multilayer unit including at least a first layer and a second layer non-covalently associated with one another,
wherein at least one of the first layer or the second layer of the at least one multilayer unit is decomposable, and at least one of the first layer or the second layer of the at least one multilayer unit comprises a binding agent that binds to an entity so as to retain the entity in association with the device.