| 发明名称 |
ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES |
| 摘要 |
The present invention provides for anti-EFNA4 antibody-drug conjugates and methods for preparing and using the same. |
| 申请公布号 |
US2015125472(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201414525442 |
申请日期 |
2014.10.28 |
| 申请人 |
Pfizer, Inc. ;Stem CentRx, Inc. |
发明人 |
DAMELIN Marc Isaac;KHANDKE Kiran Manohar;SAPRA Puja;BANKOVICH Alexander John;DYLLA Scott J. |
| 分类号 |
A61K31/704;C07K16/30;A61K47/48 |
主分类号 |
A61K31/704 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody-drug conjugate of the formula:
Ab-(L-D), wherein: (a) Ab is an antibody, or antigen-binding fragment thereof, that binds to EFNA4; and (b) L-D is a linker-drug moiety, wherein L is a linker and D is a drug, and wherein D is calicheamicin. |
| 地址 |
New York NY US |
