摘要 |
The present invention provides EFNA4 antibody-drug conjugates and their use in detection, prophylaxis, and therapy of EFNA4 associated disorders. An EFNA4 antibody-drug conjugate of the invention is generally of the formula: Ab-(L-D), wherein Ab is an antibody, or antigen-binding fragment thereof, that binds to EFNA4, or an EFNA4- binding fragment thereof; and L-D is a linker-drug moiety, wherein L is a linker, and D is a drug, preferably a calicheamicin. The Ab of the disclosed antibody-drug conjugate can be any EFNA4-binding antibody. In some aspects of the invention, the Ab is a chimeric, CDR-grafted, humanized, or a recombinant human antibody, or EFNA4- binding fragment thereof. In some aspects of the invention, the Ab is an internalizing antibody and/or a neutralizing antibody. |
申请人 |
PFIZER INC.;STEMCENTRX, INC. |
发明人 |
DAMELIN, MARC ISAAC;KHANDKE, KIRAN MANOHAR;SAPRA, PUJA;BANKOVICH, ALEXANDER JOHN;DYLLA, SCOTT J. |