发明名称 Modulators Of TNF-Alpha Signaling
摘要 The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:;
申请公布号 US2015126512(A1) 申请公布日期 2015.05.07
申请号 US201414553313 申请日期 2014.11.25
申请人 GENZYME CORPORATION 发明人 Sneddon Scott F.;Kane John L.;Hirth Bradford H.;Vinick Frederic;Qiao Shuang;Nahill Sharon R.;Williams John M.;Biemann Hans-Peter
分类号 A61K31/53 主分类号 A61K31/53
代理机构 代理人
主权项 1. A method of treating TNF-α mediated inflammation in a patient in need of such treatment, comprising administering to the patient a therapeutically effective amount of a compound of Formula (II): or a physiologically acceptable salt thereof, wherein, R5 is substituted or unsubstituted aralkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted cycloalkylalkyl; R6 is —H or —NR13R14; R7 is substituted or unsubstituted phenyl; and R13 and R14 are each, independently, —H, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl; or R13 and R14 together with the nitrogen to which they are attached are a heterocycloalkyl.
地址 Cambridge MA US