| 摘要 |
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, a sleep disorder and the like. The present invention relates to a compound represented by the formula (I):;;wherein R1 is an optionally substituted amino group or an optionally substituted cyclic amino group, R2 and R3 are each independently a hydrogen atom or a substituent, X is —CH═ or —N═, and ring A is an optionally substituted 5- to 10-membered ring, or a salt thereof. |
| 主权项 |
1. A compound represented by the formula (I) wherein R1 is an optionally substituted amino group or an optionally substituted cyclic amino group, R2 and R3 are each independently a hydrogen atom or a substituent, X is —CH═ or —N═, and ring A is an optionally substituted 5- to 10-membered ring, or a salt thereof, provided that (1) R1 is not a methoxy(methyl)amino group; (2) R1 is not an amino group substituted by a substituent selected from an optionally substituted saturated azabicyclo ring group and a tetrazolyl group; (3) R1 is not a group represented by the formula wherein Ra is a phenyl lower alkyl group optionally having, as substituent(s) on the phenyl ring, 1 to 3 groups selected from the group consisting of a halogen atom, a lower alkyl group and a nitro group and optionally having, on the lower alkyl group, a hydroxyl group as a substituent, a hydrogen atom, a lower alkyl group, a benzoyl lower alkyl group, a phenyl lower alkenyl group, a benzoyl group optionally having, on the phenyl ring, a lower alkoxy group as a substituent, or a phenyl group, and Rb is a hydrogen atom or a phenyl lower alkyl group; (4) R1 is not a group represented by the formula wherein D is an alkylene group or an alkylene group discontinued by at least one double bond, Rc is a hydrogen atom or a lower alkyl group, a partial structure Rf is a phenyl group, a nitrogen atom-containing heteroaryl group or a diphenylmethyl group, Rg is a hydrogen atom or a lower alkyl group, n is 2 or 3, Rh and Ri are each a phenyl group, the phenyl group or phenyl moiety in the definitions of Rf, Rh and Ri is optionally substituted by 1 to 3 halogen atoms, a lower alkyl group, a trifluoromethyl group, a lower alkoxy group or a hydroxyl group; (5) ring A is not an unsubstituted phenyl group; and (6) when both R2 and R3 are hydrogen atoms, ring A is not an unsubstituted C3-6 cycloalkyl group, or a phenyl group having a halogen atom or a methyl group at the 4-position. |
