| 发明名称 |
METHODS OF REMOVING ALPHA-GALACTOSE |
| 摘要 |
Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided. |
| 申请公布号 |
US2015126453(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201414532089 |
申请日期 |
2014.11.04 |
| 申请人 |
LifeCell Corporation |
发明人 |
Xu Hui;Huang Li Ting;Wan Hua;Owens Rick T.;Bachrach Nathaniel |
| 分类号 |
A61L27/36;G01N33/573;A61L27/24;A61L27/58;A61L27/54 |
主分类号 |
A61L27/36 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a tissue product, comprising
selecting at least one collagen-containing tissue matrix containing galactose alpha-1,3-galactose moieties; and contacting the at least one tissue matrix with at least one proteolytic enzyme selected from alcalase, bromelain, trypsin, and dispase under conditions sufficient to remove galactose alpha-1,3-galactose moieties from the tissue. |
| 地址 |
Branchburg NJ US |
