发明名称 |
METHODS OF MAKING 15-HYDROXY FATTY ACID DERIVATIVES |
摘要 |
The present disclosure provides methods of making 15-hydroxy fatty acid derivatives, such as 15-(S)-hydroxyeicosatrienoic acid (HETrE or 15-(S)-HETrE) or 15(S)-hydroxyeicosapentaenoic acid (HEPE or 15(S)-HEPE) from the corresponding fatty acid (e.g., dihomo-Y-linolenic acid (DGLA) or eicosapentaenoic acid (EPA), respectively). In some embodiments, the method comprises contacting the fatty acid with an oxidizing agent (e.g., a lipoxygenase and oxygen) in the presence of a reducing agent (e.g., cysteine) to form the 15-hydroxy fatty acid derivatives in a single reaction vessel. |
申请公布号 |
WO2015063617(A2) |
申请公布日期 |
2015.05.07 |
申请号 |
WO2014IB03086 |
申请日期 |
2014.10.29 |
申请人 |
DIGNITY SCIENCES LIMITED;MANKU, MEHAR;COUGHLAN, DAVID;DOWNES, BILL |
发明人 |
MANKU, MEHAR;COUGHLAN, DAVID;DOWNES, BILL |
分类号 |
C07C51/367 |
主分类号 |
C07C51/367 |
代理机构 |
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代理人 |
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