ENZYME MATRICES FOR USE WITH ETHYLENE OXIDE STERILIZATION

摘要

The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4′-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors.

主权项

1. A method of making an analyte sensor apparatus comprising:
disposing a working electrode, a reference electrode, and a counter electrode on a base layer; disposing an analyte sensing layer over the working electrode, wherein: the analyte sensing layer comprises glucose oxidase disposed within a polyvinyl alcohol polymer comprising N-methyl-4(4′-formylstyryl)pyridinium (PVA-SbQ); the PVA-SbQ polymer is selected for an ability to inhibit damage to glucose oxidase by ethylene oxide; and disposing an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough; so that an analyte sensor apparatus is made.