发明名称 |
痴呆の予防および治療におけるL−n−ブチルフタリドの適用 |
摘要 |
PROBLEM TO BE SOLVED: To provide a method for preventing and treating dementia, especially Alzheimer's disease and vascular dementia.SOLUTION: Optically-active L-n-butylphthalide is represented by formula (I). The L-n-butylphthalide is obtained by first chemically synthesizing a racemic body of n-butylphthalide and chemically dividing the racemic body into two structural components in order to produce a levorotatory isomer of the n-butylphthalide. An effective dosage of the L-n-butylphthalide for the treatment is 0.1-100 mg/kg/day. |
申请公布号 |
JP5714524(B2) |
申请公布日期 |
2015.05.07 |
申请号 |
JP20120045959 |
申请日期 |
2012.03.01 |
申请人 |
石薬集団中奇制薬技術(石家庄)有限公司;中国医学科学院薬物研究所 |
发明人 |
馮亦璞;王暁良;王栄端;彭英;楊麗英;楊靖華;孫京国;楊占坤 |
分类号 |
A61K31/365;A61P25/28;C07D307/88 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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