| 摘要 |
<p>The present invention provides a novel oxazolidinone derivative of the formula (I):
wherein
Ring A is
(A-1) a 7-membered monocyclic heterocycle containing three N atoms;
(A-2) a 7-membered monocyclic heterocycle containing two N atoms and one O atom; or
(A-3) a 7-membered monocyclic heterocycle containing two N atoms and one S atom, SO or SO 2 ,
wherein said monocyclic heterocycle is optionally substituted, optionally unsaturated and optionally fused with another ring;
X 1 is a single bond, or a heteroatom-containing group selected from the group consisting of -O-, -S-, -NR 2 -, -CO-, -CS-, -CONR 3 -, -NR 4 CO-, -SO 2 NR 5 -, and -NR 6 SO 2 -, wherein R 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom-containing group;
Ring B is optionally substituted carbocycle or optionally substituted heterocycle; and
R 1 is hydrogen, or an organic residue which is able to bind to the 5-position of the oxazolidinone ring in oxazolidinone antimicrobial agents,
pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.</p> |
