发明名称 |
MULTICOMPONENT CRYSTALS COMPRISING IMATINIB MESILATE AND SELECTED CO-CRYSTAL FORMERS |
摘要 |
Novel solid forms of imatinib mesilate comprising as active ingredient 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]-benzamide methanesulfonic acid salt and as co-crystal former benzoic acid, fumaric acid or succinic acid are described. The said multi-component crystalline forms possess improved physical and biological properties with respect to the crystalline forms of the active pharmaceutical ingredient previously known. |
申请公布号 |
US2015126520(A1) |
申请公布日期 |
2015.05.07 |
申请号 |
US201314406264 |
申请日期 |
2013.06.18 |
申请人 |
BASF SE |
发明人 |
Chiodo Tiziana;Hellmann Rolf;Vossen Marcus;Salvador Beate;Hafner Andreas;Hintermann Tobias |
分类号 |
C07D401/04;C07C55/10;C07C57/15;C07C63/06 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
1. A crystalline material, comprising 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]-benzamide methanesulfonic acid salt and a carboxylic acid compound selected from the group consisting of benzoic acid, fumaric acid, and succinic acid. |
地址 |
Ludwigshafen DE |