COMPETITIVE LIGAND BINDING ASSAY FOR DETECTING NEUTRALIZING ANTIBODIES
摘要
A immunogenicity assay for detecting the presence of neutralizing antibodies to a biotherapeutic protein wherein the biotherapeutic protein has been administered to a patient in need, comprising the steps of (a) obtaining a sample from the patient; (b) incubating the sample in the presence of a capture reagent; and (c) adding a detecting reagent, wherein a decreased signal relative to a control sample indicates the presence of a neutralizing antibody to the biotherapeutic agent.
申请公布号
CA2928730(A1)
申请公布日期
2015.05.07
申请号
CA20142928730
申请日期
2014.10.30
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
RAJADHYAKSHA, MANOJ;SHYU, GARY;GEORGAROS, CAMILLE;PARTRIDGE, MICHAEL;TORRI, ALBERT