| 发明名称 |
MonoPEGylated human growth hormone |
| 摘要 |
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins. |
| 申请公布号 |
EP2305804(B1) |
申请公布日期 |
2015.05.06 |
| 申请号 |
EP20100012486 |
申请日期 |
2000.01.14 |
| 申请人 |
BOLDER BIOTECHNOLOGY, INC. |
发明人 |
COX, GEORGE N.;DOHERTY, DANIEL H.;ROSENDAHL, MARY S. |
| 分类号 |
C12N15/00;C12N15/09;A61K38/00;A61K38/04;A61K38/21;A61K38/22;A61K38/27;A61K47/48;A61P5/02;A61P7/06;A61P43/00;C07K1/113;C07K14/47;C07K14/475;C07K14/505;C07K14/555;C07K14/56;C07K14/575;C07K14/61;C07K14/72;C07K17/08;C12N15/20;C12P21/02;C12R1/19 |
主分类号 |
C12N15/00 |
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