| 摘要 |
A method and apparatus for charge stripping analyte ions comprises reacting the analyte ions with reagent ions or charged particles (for example, electron transfer dissociation ETD), then urging the reacted analyte ions through a neutral, inert gas such that said analyte ions interact or collide with the gas molecules in a manner that reduces the charge state of the reacted analyte ions, preferably without fragmentation, thereby forming product ions of reduced charge state. Alternatively, after undergoing reaction with charged particles or reagent ions, the reacted analyte ions can be urged onto a solid surface in order to reduce their charge state. Alternatively, after undergoing reaction with charged particles or reagent ions, the reacted analyte ions can be illuminated with photons in order to reduce their charge state. A mass spectrometer or mobility spectrometer making use of these methods is also provided. |
