Use of dimiracetam in the treatment of chronic pain

摘要

The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose.