发明名称 |
LIPOSOMES ACTIVE IN-VIVO ON NEURODEGENERATIVE DISEASES (IN PARTICULAR ALZHEIMER'S DISEASE) |
摘要 |
New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease. |
申请公布号 |
EP2866790(A1) |
申请公布日期 |
2015.05.06 |
申请号 |
EP20130733948 |
申请日期 |
2013.06.05 |
申请人 |
UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA |
发明人 |
RE, FRANCESCA;SANCINI, GIULIO;FORLONI, GIANLUIGI;SALMONA, MARIO;MASSERINI, MASSIMO |
分类号 |
A61K9/127;A61K47/48 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|