MORPHINAN DERIVATIVE

摘要

A morphinan derivative represented by the following general formula (I):
(in the formula, R 1 represents hydrogen, C 1-6 alkyl, cycloalkylalkyl (the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms), aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like,
R 2 represents hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 6-10 aryl, aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like,
R 3 , R 4 and R 5 represent hydrogen, hydroxy, carbamoyl, C 1-6 alkoxy, C 6-10 aryloxy and the like,
R 6a , R 6b , R 7 , R 8 , R 9 , and R 10 represent hydrogen and the like,
X represents O or CH 2 , and
Y represents C=O, SO 2 , an atomic bond and the like), or an acid addition salt thereof is used as an analgesic.